Sodium Hydroxide → HCID 9869513, compound

Participants

Reaction Steps

A solution of N-[3-[4-methyl-1-(4-phenyl-1-piperazinyl)-cyclohexyl]phenyl]-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxamide (cis isomer) (34 mg, 0.066 mmol) was dissolved in 4 mL of 6N HCl and the clear homogeneous solution was allowed to stand for 1 h at room temperature. The reaction mixture was made basic with 1N NaOH, extracted with CH2Cl2, dried (Na2SO4) and concentrated to give the crude ketone. The residue was triturated with 30% EtOAc/hexanes to yield colorless crystals of 4-(oxo)-N-[3-[4-methyl-1-(4-phenyl-1-pipera-zinyl)-cyclohexyl]phenyl]-1-piperidinecarboxamide (cis isomer). mp=~173° C. (decomp.).

Provenance & Evidence