Water → HCID 19608315, compound

Participants

Reaction Steps

A mixture of 3,5-bis(trifluoromethyl)-benzoyl chloride (1.1 g) and triethylamine (0.4 g) in DCM (40 ml) was stirred. 3-(3-methyl-1,2,4-thiadiazol-5-yl)-6-(1-piperazinyl)-pyridazine (1.1 g) was added portionwise. The mixture was stirred at room temperature for 3 hours. Triethylamine was added. The mixture was stirred at room temperature for 1 hour. Water was added and the mixture was extracted three times with DCM. The combined organic layer was dried, filtered and the solvent was evaporated. The residue was crystallized from methanol. The precipitate was filtered off and dried, yielding 0.91 g (45%) of 1-[3,5-bis(trifluoromethyl)benzoyl]-4-[6-(3-methyl-1,2,4-thiadiazol-5-yl)-3-pyridazinyl]piperazine (compound 131).

Provenance & Evidence