HCID 19608428, compound → HCID 178422871, compound

HRID 1602873Notes

Reaction equation

HRID 1602873 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[CH3:7][C:8]1([CH2:13][CH2:14][C:15](=O)[CH2:16][C:17](OC)=[O:18])[O:12][CH2:11][CH2:10][O:9]1>>[OH:18][C:17]1[N:3]2[N:4]=[CH:5][CH:6]=[C:2]2[N:1]=[C:15]([CH2:14][CH2:13][C:8]2([CH3:7])[O:9][CH2:10][CH2:11][O:12]2)[CH:16]=1

Participants

3

Reactant 2

HCID 19608428HCID 19608428, compoundHCID 178418806HCID 178418806, compound

Product 1

HCID 178422871HCID 178422871, compoundYield 84.5%

Procedure

Using 0.9 g of 3-aminopyrazole and 1.9 g of methyl 2-methyl-β-oxo-1,3-dioxolane-2-valerate, the procedure of Reference Example 1 was followed. As a result, 1.85 g of 7-hydroxy-5-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]pyrazolo[1,5-a]pyrimidine was obtained as colorless crystals.

Sources & evidence

ORD record
ord-fde91ee3bdb84ae1ba4355c7eb152942
Source dataset
uspto-grants-1999_11
Patent number
US05985882

Reaction notes

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