Hydrochloric Acid → HCID 178467745, compound

Participants

Reaction Conditions

Reaction Steps

The compound obtained in step (2), 5.7 g, was dissolved in 120 ml of methanol. Sodium borohydride, 0.53 g, was added to the solution under ice-cooling. The mixture was stirred at 0° C. for 2 hours. After completion of the reaction, the reaction mixture was acidified by adding diluted hydrochloric acid dropwise and then extracted with chloroform. The organic layer was collected, washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was recrystallized from ethanol-n-hexane to provide 4.16 g of 7-hydroxy-5-(3-hydroxybutyl)pyrazolo[1,5-a]pyrimidine as colorless crystals.

Provenance & Evidence