Pyridine → HCID 178476213, compound

HRID 1602876Notes

Reaction equation

HRID 1602876 reaction equation
[OH:1][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([CH2:11][CH2:12][CH:13]([OH:15])[CH3:14])[CH:3]=1.N1C=CC=CC=1.[C:22](OC(=O)C)(=[O:24])[CH3:23]>>[C:22]([O:15][CH:13]([CH3:14])[CH2:12][CH2:11][C:4]1[CH:3]=[C:2]([OH:1])[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=1)(=[O:24])[CH3:23]

Participants

4

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 178467745HCID 178467745, compound

Product 1

HCID 178476213HCID 178476213, compound

Procedure

The crystals obtained in step (3), 4.16 g, were dissolved in 40 ml of acetic anhydride and 40 ml of pyridine and stirred at room temperature for 30 minutes. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was recrystallized from methanol-diethyl ether to provide 4.2 g of 5-(3-acetoxybutyl)-7-hydroxypyrazolo[1,5-a]pyrimidine as colorless crystals.

Workup

  1. customAfter completion of the reaction
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. customthe residue was recrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-48363369c29b491694ff627873ec3c4a
Source dataset
uspto-grants-1999_11
Patent number
US05985882

Reaction notes

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