HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Methyl 4'-[(3-butyl-1,4-dihydro-4-oxo-1-quinolinyl)-methyl](1,1'-biphenyl)-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-butyl-4-(1H)-quinolinone | HCID 19595341 | — |
| Reactant | Methyl bromomethyl-(1,1'-biphenyl)-2-carboxylate | HCID 19608489 | — |
| Product | Methyl 4'-[(3-butyl-1,4-dihydro-4-oxo-1-quinolinyl)-methyl](1,1'-biphenyl)-2-carboxylate | HCID 19608515 | 94.1% |
Reaction Steps
Using the procedure of Example 1, 4.02 g of the compound of Step E of Example 1 and 5.52 g of potassium carbonate and 6.2 g of methyl bromomethyl-(1,1'biphenyl)-2-carboxylate (preparation according to EP 0,253,310) were reacted to obtain after chromatography on silica (eluant: methylene chloride-methanol (98-2)), 8 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05985894 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-e09bfba82b844c2986b63b2947192b55 |
| Source note | uspto-grants-1999_11 |