Ethanol → HCID 19608501, compound

Participants

Reaction Steps

A mixture of 270 mg of the product of Example 7, 5 ml of a 5N sodium hydroxide solution and 5 ml of ethanol was stirred for 2 hours at reflux and the mixture was poured into water and acidified with sodium hydrogen phosphate. Extraction was carried out with ethyl acetate and the extracts were washed with water, dried and evaporated to dryness. The residue was chromatographed on silica (eluant: methylene chloride-methanol (9-1)) and the product was impasted in a mixture of 5 ml of ethyl acetate and 5 ml of isopropyl ether to obtain 90 mg of the desired compound melting at 155° C.

Provenance & Evidence