Sodium Hydroxide → HCID 19608478, compound

HRID 1602943Notes

Reaction equation

HRID 1602943 reaction equation
[CH2:1]([C:5]1[C:14](=[O:15])[C:13]2[C:8](=[C:9]([Br:16])[CH:10]=[CH:11][CH:12]=2)[N:7]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[C:25]([C:30]([O:32]C)=[O:31])=[CH:26][CH:27]=[CH:28][CH:29]=3)=[CH:20][CH:19]=2)[CH:6]=1)[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>C(O)C>[CH2:1]([C:5]1[C:14](=[O:15])[C:13]2[C:8](=[C:9]([Br:16])[CH:10]=[CH:11][CH:12]=2)[N:7]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([C:24]3[C:25]([C:30]([OH:32])=[O:31])=[CH:26][CH:27]=[CH:28][CH:29]=3)=[CH:22][CH:23]=2)[CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19608480HCID 19608480, compound

Product 1

HCID 19608478HCID 19608478, compoundYield 32.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using the procedure of Example 2, 380 mg of the product of Example 17 and 10 ml of N sodium hydroxide and 5 ml of ethanol were reacted to obtain 120 mg of the desired product melting at 180° C. after being crystallized from ethyl acetate.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-60ae2a113f3542d69ed9759433847d15
Source dataset
uspto-grants-1999_11
Patent number
US05985894

Reaction notes

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