HCID 18394974, compound → 5-(9-ethylcarbazol-3-ylmethyl)-2',3',5'-tris-O-((1,1-dimethylethyl)dimethylsilyl)uridine

Participants

Reaction Steps

The product of step (i) (15.83 g) was subjected to hydrogenolysis at 2.5 atmospheres in ethanol (200 ml) using 10% palladium on charcoal (1 g) until reaction was complete by thin layer chromatographical analysis. The catalyst was filtered and the mother liquor collected. The solvent was removed under reduced pressure. The remaining residue was purified by flash silica-gel chromatography to afford 5-(9-ethylcarbazol-3-ylmethyl)-2',3',5'-tris-O-((1,1-dimethylethyl)dimethylsilyl)uridine as a yellow foam.

Provenance & Evidence