4,4'-Dimethoxybenzophenone → HCID 18394994, compound

HRID 1602965Notes

Reaction equation

[CH3:1][C:2]([Si:5]([CH3:38])([CH3:37])[O:6][C@@H:7]1[C@H:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])[C@@H:10]([CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[O:9][C@H:8]1[N:29]1[CH:36]=[CH:35][C:33](=[O:34])[NH:32][C:30]1=[O:31])([CH3:4])[CH3:3].[CH3:39][O:40][C:41]1[CH:56]=[CH:55][C:44]([C:45]([C:47]2[CH:52]=[CH:51][C:50]([O:53][CH3:54])=[CH:49][CH:48]=2)=[O:46])=[CH:43][CH:42]=1>>[OH:46][C:45]([C:35]1[C:33](=[O:34])[NH:32][C:30](=[O:31])[N:29]([CH:36]=1)[C@@H:8]1[O:9][C@H:10]([CH2:20][O:21][Si:22]([C:25]([CH3:26])([CH3:27])[CH3:28])([CH3:23])[CH3:24])[C@@H:11]([O:12][Si:13]([C:16]([CH3:17])([CH3:18])[CH3:19])([CH3:14])[CH3:15])[C@H:7]1[O:6][Si:5]([C:2]([CH3:1])([CH3:3])[CH3:4])([CH3:38])[CH3:37])([C:44]1[CH:55]=[CH:56][C:41]([O:40][CH3:39])=[CH:42][CH:43]=1)[C:47]1[CH:48]=[CH:49][C:50]([O:53][CH3:54])=[CH:51][CH:52]=1

Participants

Reactant 2

HCID 70324,4'-Dimethoxybenzophenone

HCID 10841090o,o,o-Tris(tert-butyldimethylsilyl)uridine

Product 1

HCID 18394994HCID 18394994, compound

Procedure

5-(Hydroxy-1,1-bis(4-methoxyphenyl)methyl)-2',3',5'-tris-O-((1,1-dimethylethyl)dimethylsilyl)uridine was prepared from 2',3',5'-tris-O-((1,1-dimethylethyl)dimethylsilyl)uridine according to the method of Example 1 step (i) (but using 4,4'-dimethoxybenzophenone instead of benzophenone).

Sources & evidence

ORD record: ord-3e625107129c4ea4af56b85b58a947c8
Source dataset: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05985849

Reaction notes

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