Trifluoroacetic acid → HCID 54298480, compound

Participants

Reaction Steps

The product of step (i) (3.8 g) was dissolved in dichloromethane (75 ml) and triethylsilane (0.8 ml) and was treated with trifluoroacetic acid(3.59 ml). After stirring for 1 hour at room temperature, the volatiles were removed under reduced pressure and any remaining traces removed by azeotroping four times with toluene. The residue was treated with 1M tetra-n-butylammonium fluoride solution in tetrahydrofuran (15 ml). After stirring for 36 hours, the solvent was removed under reduced pressure and the residue was purified by silica-gel chromatography eluting with 2% methanol in ethyl acetate to afford 5-(1,1-bis(4-methoxyphenyl)methyl)uridine as a white solid (1.4 g).

Provenance & Evidence