HCID 53771011, compound → HCID 54161311, compound

Participants

Reaction Steps

The product of step (iii) (3.5 g) was dissolved in acetonitrile (70 ml) and treated with a 1:1 hydrofluoric acid-pyridine complex (20 ml). After 3 hours the mixture was quenched with saturated aqueous sodium carbonate solution (100 ml) and the product extracted into ethyl acetate. The organic phase was collected, dried over magnesium sulphate and the solvent was removed under reduced pressure. The residue was purified by flash silica-gel chromatography eluting with chloroform-methanol mixtures to afford 5-((3-phenoxy)phenylmethyl)-4-thiouridine as a yellow powder (1.5 g).

Provenance & Evidence