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4-Nitrobenzoyl chloride → 1-(4-Nitrobenzoyl)-1,2,3,4-tetrahydroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrobenzoyl chloride | HCID 8502 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-(4-Nitrobenzoyl)-1,2,3,4-tetrahydroquinoline | HCID 3763693 | 67.1% |
反応手順
To a solution of 1,2,3,4-tetrahydroquinoline (28.7 g) in acetone (400 ml) and water (200 ml) is added potassium carbonate (38.8 g), and thereto is added p-nitrobenzoyl chloride (40 g) under ice-cooling and the mixture is stirred at room temperature overnight. To the reaction mixture is added a suitable amount of water. The precipitated crystal is collected by filtration and dried to give 1-(4-nitrobenzoyl)-1,2,3,4-tetrahydroquinoline (40.8 g) as white powder, m.p. 86-88° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05985869 |
| 出典データセット | uspto-grants-1999_11 |
| ORD ID | ord-ff4e11a80a77437b821f09ddbfbb00a9 |
| 出典メモ | uspto-grants-1999_11 |