2-(Bromomethyl)benzonitrile → tert-butyl (3RS,4RS)-3-(2-cyano-benzyloxy)-4-(4-fluoro-phenyl)-piperidine-1-carboxylate

HRID 160311Notes

Reaction equation

HRID 160311 reaction equation
[Br:22][CH2:23][c:24]1[c:25]([C:26]#[N:27])[cH:28][cH:29][cH:30][cH:31]1.[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([OH:21])[CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[cH:6][cH:7]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([O:21][CH2:23][c:24]3[c:25]([C:26]#[N:27])[cH:28][cH:29][cH:30][cH:31]3)[CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 895992-(Bromomethyl)benzonitrileHCID 45074236Tert-butyl 4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate

Product 1

HCID 86604452tert-butyl (3RS,4RS)-3-(2-cyano-benzyloxy)-4-(4-fluoro-phenyl)-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-3fd880a280eb4d74ab3b2d55a90d3321
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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