Sodium Hydroxide → HCID 15289130, compound

HRID 1603224Notes

Reaction equation

HRID 1603224 reaction equation
[CH2:1]([N:8]1[C:16](=[O:17])[CH:15]2[CH:10]([C:11]3([C:19]([O:21]CC)=[O:20])[CH2:18][CH:14]2[CH:13]=[CH:12]3)[C:9]1=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[CH2:1]([N:8]1[C:16](=[O:17])[CH:15]2[CH:10]([C:11]3([C:19]([OH:21])=[O:20])[CH2:18][CH:14]2[CH:13]=[CH:12]3)[C:9]1=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15289129HCID 15289129, compound

Product 1

HCID 15289130HCID 15289130, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

30 g (90 mmol) of ethyl 4-benzyl-3,5-dioxo-4-azatricyclo[5.2.1.02,6 ]dec-8-ene-1-carboxylate are heated under reflux with 5.3 g (0.13 mol) of NaOH in 150 ml of methanol overnight. The mixture is concentrated, the residue is taken up in 150 ml of water and the mixture is acidified with hydrochloric acid. The product which crystallizes out is filtered off with suction, washed with water and dried in air.

Workup

  1. concentrationThe mixture is concentrated
  2. customThe product which crystallizes out
  3. filtrationis filtered off with suction
  4. washwashed with water
  5. customdried in air

Sources & evidence

ORD record
ord-e83345a4cf4f4d60a93d810889983f6e
Source dataset
uspto-grants-1999_11
Patent number
US05986105

Reaction notes

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