反应详情

--Quantities: 5-bromo-2-iodopyrimidine 2 (5.05 g, 17.7 mmol), 2-fluoro-4-benzyloxyphenylboronic acid 27 (4.84 g, 19.7 mmol), tetrakis(triphenylphosphine)palladium (680 mg, 0.59 mmol), 2M sodium carbonate (50 ml), DME (50 ml). The experimental procedure was as described for compound 4 to yield the benzyloxyfluorophenylpyrimidine 28 (3.34 g, 53%) (from MeOH), m.p. 124.2° C.; νmax /cm-1 (KBr) 3030, 2860, 1615s, 1430, 1420, 1320, 1215, 1020 and 830, δ 5.22 (2H, s, CH2), 6.75-6.89 (2H, m, 3'- and 5'-H), 7.32-7.48 (5H, m, Ph), 8.06 (1H, t, 6'-H) and 8.85 (2H, s, 4-and 6-H); m/z 360 (M+), 358 (M+), 269 (M+ -PhCH2), 267 (M+ -PhCH2), 247, 221 and 91.