反应详情

A 20 ml portion of a 2N aqueous sodium hydroxide solution was added to 100 ml of an ethanol solution containing 5.727 g of ethyl 2-(N-t-butoxycarbonylamino)methylthiazol-4-carboxylate, and the mixture was then stirred at room temperature for 45 minutes. After adjustment to pH 5 with 2N hydrochloric acid, the solvent was evaporated under reduced pressure. Further, the solution was dissolved in 300 ml of ethanol under heating, and after the removal of a salt by filtration, the solvent was evaporated under reduced pressure to obtain 4.228 g of 2-(N-t-butoxycarbonylamino)methylthiazol-4-carboxylic acid as a milky white solid.

1. customAfter adjustment to pH 5 with 2N hydrochloric acid, the solvent was evaporated under reduced pressure
2. dissolutionFurther, the solution was dissolved in 300 ml of ethanol
3. temperatureunder heating
4. customafter the removal of a salt
5. filtrationby filtration
6. customthe solvent was evaporated under reduced pressure