Tetrahydrofuran → HCID 19605215, compound

Participants

Reaction Conditions

Reaction Steps

A 9.4 ml portion of a 1.5N diisobutylaluminum hydride/n-hexane solution was added to 10 ml of an anhydrous tetrahydrofuran solution containing 0.758 g of 2,5-diethoxycarbonylimidazo[5,1-b]thiazole, and the mixture was then stirred at -78° C. for 2 hours. Then, 10 ml of methanol was added to the reaction solution, and after stirring for 30 minutes, the solution was subjected to Celite filtration. The solvent was evaporated under reduced pressure, and the resulting crude product was purified by a silica gel column chromatograph to obtain 383.3 mg of the title compound.

Provenance & Evidence