HCID 19605074, compound → HCID 19605097, compound

HRID 1603495Notes

Reaction equation

HRID 1603495 reaction equation
[OH:1][CH:2]([C:4]1[N:5]2[CH:11]=[N:10][CH:9]=[C:6]2[S:7][CH:8]=1)[CH3:3]>ClCCl.[O-2].[O-2].[Mn+4]>[C:2]([C:4]1[N:5]2[CH:11]=[N:10][CH:9]=[C:6]2[S:7][CH:8]=1)(=[O:1])[CH3:3]

Participants

4

Reactant 1

HCID 19605074HCID 19605074, compound

Product 1

HCID 19605097HCID 19605097, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

A 651 mg potion of 3-(1-hydroxyethyl)imidazo[5,1-b]thiazole was dissolved in 130 ml of dichloromethane, and 9.77 g of active manganese dioxide was then added, followed by stirring at room temperature for 4 hours. After the completion of the reaction, insolubles were removed therefrom by filtration, followed by washing with dichloromethane. The filtrate was concentrated to dryness under reduced pressure to obtain 550 mg of the title compound.

Workup

  1. customAfter the completion of the reaction, insolubles
  2. customwere removed
  3. filtrationby filtration
  4. washby washing with dichloromethane
  5. concentrationThe filtrate was concentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-24cc940b28c247e7a3e878169158ff7c
Source dataset
uspto-grants-1999_11
Patent number
US05990101

Reaction notes

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