3-(Aminosulfonyl)aminomethylimidazo[5,1-b]thiazole → HCID 178427987, compound

HRID 1603514Notes

Reaction equation

HRID 1603514 reaction equation
C(OC([O:7][C@@H:8]([C@H:10]1[C:25](=[O:26])[N:12]2[C:13]([C:19]([O:21]CC=C)=[O:20])=[C:14]([CH2:17]O)[CH:15]([CH3:16])[C@H:11]12)[CH3:9])=O)C=C.[NH2:27][S:28]([NH:31][CH2:32][C:33]1[N:34]2[CH:40]=[N:39][CH:38]=[C:35]2[S:36][CH:37]=1)(=[O:30])=[O:29]>>[OH:7][C@@H:8]([C@H:10]1[C:25](=[O:26])[N:12]2[C:13]([C:19]([O-:21])=[O:20])=[C:14]([CH2:17][N:39]3[CH:38]=[C:35]4[S:36][CH:37]=[C:33]([CH2:32][NH:31][S:28]([NH2:27])(=[O:29])=[O:30])[N+:34]4=[CH:40]3)[CH:15]([CH3:16])[C@H:11]12)[CH3:9]

Participants

3

Reactant 2

HCID 196051643-(Aminosulfonyl)aminomethylimidazo[5,1-b]thiazoleHCID 131721461allyl (5R,6S)-6-[(1R)-1-allyloxycarbonyloxyethyl]-2-hydroxymethyl-1-methyl-1-carbapen-2-em-3-carboxylate

Product 1

HCID 178427987HCID 178427987, compoundYield 12.9%

Procedure

The same procedure as in Example 1 was repeated except that 88 mg of allyl (5R,6S)-6-[(1R)-1-allyloxycarbonyloxyethyl]-2-hydroxymethyl-1-methyl-1-carbapen-2-em-3-carboxylate and 87 mg of 3-(aminosulfonyl)aminomethylimidazo[5,1-b]thiazole were used, thereby obtaining 14.2 mg of the title compound.

Sources & evidence

ORD record
ord-b699aac39f6c4567bbe808299eaaac6c
Source dataset
uspto-grants-1999_11
Patent number
US05990101

Reaction notes

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