Imidazo[5,1-b]thiazole → HCID 178462309, compound

HRID 1603515Notes

Reaction equation

HRID 1603515 reaction equation
C(OC([O:7][C@@H:8]([C@H:10]1[C:24](=[O:25])[N:12]2[C:13]([C:18]([O:20]CC=C)=[O:19])=[C:14]([CH2:16]O)[CH2:15][C@H:11]12)[CH3:9])=O)C=C.[S:26]1[CH:30]=[CH:29][N:28]2[CH:31]=[N:32][CH:33]=[C:27]12>>[OH:7][C@@H:8]([C@H:10]1[C:24](=[O:25])[N:12]2[C:13]([C:18]([O-:20])=[O:19])=[C:14]([CH2:16][N:32]3[CH:33]=[C:27]4[S:26][CH:30]=[CH:29][N+:28]4=[CH:31]3)[CH2:15][C@H:11]12)[CH3:9]

Participants

3

Reactant 2

HCID 21262404Imidazo[5,1-b]thiazoleHCID 131721462HCID 131721462, compound

Product 1

HCID 178462309HCID 178462309, compoundYield 12.5%

Procedure

The same procedure as in Example 1 was repeated except that 43 mg of allyl (5R,6S)-6-[(1R)-1-allyloxycarbonyloxyethyl]-2-hydroxymethyl-1-carbapen-2-em-3-carboxylate and 31 mg of imidazo[5,1-b]thiazole were used, thereby obtaining 5.1 mg of the title compound.

Sources & evidence

ORD record
ord-e97c9df5d75d4261afdadb83cda3a529
Source dataset
uspto-grants-1999_11
Patent number
US05990101

Reaction notes

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