5-Hydroxymethylimidazo[5,1-b]thiazole → HCID 178462312, compound

HRID 1603516Notes

Reaction equation

HRID 1603516 reaction equation
C(OC([O:7][C@@H:8]([C@H:10]1[C:21](=[O:22])[N:12]2[C:13]([C:18]([O-:20])=[O:19])=[C:14]([CH2:16]O)[CH2:15][C@H:11]12)[CH3:9])=O)C=C.[OH:23][CH2:24][C:25]1[N:32]2[C:28]([S:29][CH:30]=[CH:31]2)=[CH:27][N:26]=1>>[OH:7][C@@H:8]([C@H:10]1[C:21](=[O:22])[N:12]2[C:13]([C:18]([O-:20])=[O:19])=[C:14]([CH2:16][N:26]3[CH:27]=[C:28]4[S:29][CH:30]=[CH:31][N+:32]4=[C:25]3[CH2:24][OH:23])[CH2:15][C@H:11]12)[CH3:9]

Participants

3

Reactant 2

HCID 183599875-Hydroxymethylimidazo[5,1-b]thiazoleHCID 18395217(5R,6S)-6-[(1R)-1-allyloxycarbonyloxyethyl]-2-hydroxymethyl-1-carbapen-2-em-3-carboxylate

Product 1

HCID 178462312HCID 178462312, compoundYield 6.6%

Procedure

The same procedure as in Example 1 was repeated except that 43 mg of (5R,6S)-6-[(1R)-1-allyloxycarbonyloxyethyl]-2-hydroxymethyl-1-carbapen-2-em-3-carboxylate and 96 mg of 5-hydroxymethylimidazo[5,1-b]thiazole were used, thereby obtaining 3.3 mg of the title compound.

Sources & evidence

ORD record
ord-da1f432167e44dd6a9792f207276af5d
Source dataset
uspto-grants-1999_11
Patent number
US05990101

Reaction notes

Loading…