反应详情

A mixture of 200 mg of 6-amino-3H-quinazolin-4-one and 206 mg of 2,5-dimethoxybenzaldehyde in 12 ml of dry methanol is heated to 60° for 16 hours. cooling the yellow precipitate is filtered and resuspended in 10 ml of dry methanol. This mixture is treated with 85 mg of sodium cyanoborohydride and heated for some minutes until all the materials are dissolved. After stirring for 2 at room temperature, the mixture is poured into water and extracted with acetate. The combined organic extracts are dried over magnesium sulfate and evaporated in vacuo. The pure title compound is obtained by crystallisation from ethanol as colourless crystals. mp: 203-205°.

1. temperatureis heated to 60° for 16 hours
2. temperaturecooling the yellow precipitate
3. filtrationis filtered
4. additionThis mixture is treated with 85 mg of sodium cyanoborohydride
5. temperatureheated for some minutes until all the materials
6. dissolutionare dissolved
7. additionthe mixture is poured into water
8. extractionextracted with acetate
9. dry with materialThe combined organic extracts are dried over magnesium sulfate
10. customevaporated in vacuo