Hydrochloric Acid → HCID 135752753, compound

Participants

Reaction Steps

90 mg of 6-[2-(5-hydroxy-2-methoxyphenyl)ethyl]-4-methoxyquinazoline are dissolved in 8 ml of methanol and treated with 1 ml of 4 N aqueous hydrochloric acid. The mixture is stirred for 16 hours at room temperature, then poured onto 2 M aqueous pH 7 buffer and extracted with ethyl acetate. The combined organic extracts are dried over magnesium sulfate and evaporated in vacuo. The residue is chromatographed on silica gel (dichloromethane/methanol=9/1) to yield the title compound as colourless crystals. mp: 221-224°.

Provenance & Evidence