1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 54542309, compound

Participants

Reaction Steps

A mixture of 93 mg of 5-[2-(2,5-dimethoxyphenyl)ethyl]-2-acetylamino-benzoic acid butylester, 100 mg of lithium bromide, 55 mg of 1,8-diazabicyclo[5.4.0]undec-7-en and 4 ml of dry ethanol is heated to reflux for 3 hours. After neutralisation with 0.1 N aqueous hydrochloric acid, the mixture is extracted with ethyl acetate. The combined organic extracts are dried over magnesium sulfate and concentrated in vacuo. The pure title compound is obtained by silica gel chromatography (hexane/ethyl acetate=6/1) as colourless crystals. mp: 93°.

Provenance & Evidence