HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 19605759, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,5-Dimethoxyphenylacetylene | HCID 11094951 | — |
| Reactant | 6-Iodo-4-methoxyquinazoline | HCID 19605782 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 19605759 | HCID 19605759 | — |
Reaction Steps
Argon is passed through a solution of 200 mg of 6-iodo-4-methoxy-quinazoline in 12 ml of dry dimethylformamide for 15 minutes. Then 40 mg of tetrakis(triphenylphosphine)-palladium, 113 mg of (2,5-dimethoxyphenyl)acetylene, 11 mg of copper(I)iodide and 220 mg of triethylamine are added, and the mixture is heated to 60° for 2 hours. The solvent is distilled off in vacuo and the residue partitioned between water and ethyl acetate. The organic layer is separated, dried and concentrated in vacuo. The pure title compound is obtained after chromatography (silica gel, cyclohexane/ethyl acetate=2/1) as colourless crystals. mp: 103-105°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05990116 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-5c72c183a37848fbae9abcc2e483b0ac |
| Source note | uspto-grants-1999_11 |