Pyrrolidine → HCID 19605458, compound

Participants

Reaction Steps

16.8 g (0.0554 Mol) 4-(2,6-dichloro-pyridine-4-sulfonyl)-phenylamine were dissolved in dioxane (165 ml), 23.0 ml (0.2753 Mol) pyrrolidine were added at ambiente temperature and stirred for 1.5 h. The reaction mixture was then poured onto water (600 ml), stirred for 1 h and filtered. The residue on the filter was washed with water (150 ml), dissolved in tetrahydrofuran (250 ml) and treated with Na2SO4 (20.0 g) and Norit-SX-1 (1.7 g). After filtration the residue on the filter was washed with tetrahydrofuran (100 ml) and subsequently dried in a high vacuum. It was obtained 18.4 g (98%) 4-(2-chloro-6-pyrrolidin-1-yl-pyridine-4-sulfonyl)-phenylamine as a bright yellow powder; mp.: 225-226° C.

Provenance & Evidence