4-Chlorophenylboronic acid → HCID 19605528, compound

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A mixture of 191 mg (0.5 mmole) 4-(2-bromo-6-pyrrolidine-1-yl-pyridine-4-sulfonyl)-phenylamine, 86 mg (0.55 mmole) 4-chlorphenylboronic acid, 18 mg bis(triphenylphosphine)-palladium(II)-chloride is refluxed for 1.5 hours in 7 ml toluene and 2 ml 2N aqueous potassium carbonate. The solvents are removed in vacuo. Flash chromatography (silicagel, ethyl acetate/hexane 1/1) of the residue yields 147 mg (71%) pure 4-[2-(4-chloro-phenyl)-6-pyrrolidine-1-yl-pyridine-4-sulfonyl]-phenylamine as a white solid mp.: 236-237° C.

Provenance & Evidence