1,4-Dioxane → HCID 19605502, compound

Participants

Reaction Steps

0.20 g (0.00051 mol) of 4-(2,6-dibromopyridine-4-sulphonyl)-phenylamine was dissolved in 10 ml of dioxane and treated with 5.1 ml of 3-methylaminopropylamine. The mixture was stirred at room temperature for 2 hrs., the solvent was removed and the residue was chromatographed twice on silica gel, firstly with 20% methanol in dichloromethane and then with 10% methanol in dichloromethane. There was obtained 0.085 g (42%) of N-[3-(4-aminobenzenesulphonyl)-5-bromophenyl]-N'-methylpropane-1,3-diamine as a pale yellow, amorphous solid; MS (ISP): me/e=401, 399 (C15H20BrN4O2S+).

Provenance & Evidence