4-Fluorobenzenehexanamine → HCID 54269383, compound

Participants

Reaction Steps

Treatment of (3S,4R)-(4-benzylthio-3-chloro-2-oxoazetidin-1-yl)acetic acid with 6-(4-fluorophenyl)hexylamine under the conditions described for Example 86 gave the title compound as a colourless oil, 85% yield. 1H NMR δ (CDCl3) 1.3-1.6 (8H, m, 4xCH2), 2.56 (2H, t, J=7.6 Hz, CH2Ph), 3.22 (2H, m, NHCH2), 3.51, 3.81 (each 1H, d, J=16.5 Hz, NCH2), 3.83 (2H, s, SCH2), 4.58 (1H, d, J=1.7 Hz, H4), 4.79 (1H, d, J=1.7 Hz, H3), 5.80 (1H, m, NH), 6.95 (2H, m, 4-FPh--H), (2H, m, 4-FPh--H), 7.30 (5H, m. Ph--H)

Provenance & Evidence