Methylhydrazine → HCID 178486226, compound

HRID 1603678Notes

Reaction equation

HRID 1603678 reaction equation
[O:1]=[C:2]1[NH:10][C:9]2[NH:8][CH:7]=[N:6][C:5]=2[C:4](=S)[NH:3]1.[CH3:12][NH:13][NH2:14]>>[CH3:12][N:13]([C:4]1[C:5]2[N:6]=[CH:7][NH:8][C:9]=2[NH:10][C:2](=[O:1])[N:3]=1)[NH2:14]

Participants

3

Reactant 2

HCID 6061MethylhydrazineHCID 178518759HCID 178518759, compound

Product 1

HCID 178486226HCID 178486226, compoundYield 60%

Conditions

Temperature
120 °C

Procedure

2-Oxo-6-thioxo-1,2,3,6-tetrahydro-9H-purine (1.0 g, 5.9 mmol) were added to methylhydrazine (20 ml), and the mixture was stirred in a sealed tube for 30 minutes at 120° C. After completion of reaction, the mixture was concentrated under reduced pressure. The residual crystals were washed with 50% ethanol, and crystals collected by filtration were recrystallized from ethanol to obtain 0.64 g (yield 60%) of colorless powdery crystals (m.p.=247° C. (decomposed)).

Workup

  1. customAfter completion of reaction
  2. concentrationthe mixture was concentrated under reduced pressure
  3. washThe residual crystals were washed with 50% ethanol, and crystals
  4. filtrationcollected by filtration
  5. customwere recrystallized from ethanol

Sources & evidence

ORD record
ord-586a0447092a4fc8b32e20cb1dd4ef3c
Source dataset
uspto-grants-1999_11
Patent number
US05990118

Reaction notes

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