HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-Methoxy4-azatricyclo[5,2.2.02,6]undec-8-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3a,4,7,7a-Tetrahydro-4-methoxy-4,7-ethano-1H-isoindole-1,3(2H)-dione | HCID 15289153 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Methoxy4-azatricyclo[5,2.2.02,6]undec-8-ene | HCID 15289154 | — |
Reaction Steps
20.5 g (0.1 mol) of 1-methoxy-4-azatricyclo[5.2.2.02,6 ]undec-8-ene-3,5-dione in 100 ml of absolute tetrahydrofuran are added dropwise to 6 g of LiAlH4 in 200 ml of absolute tetrahydrofuran and the mixture is stirred under reflux overnight. 6 ml each of water, 15% strength KOH solution and water again are added, the inorganic salts are filtered off with suction and boiled out twice with tetrahydrofuran, the filtrates are concentrated and the residue is distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05990122 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-e256c5fb93804beeaa7b00106755da01 |
| Source note | uspto-grants-1999_11 |