MLS000756500 → 3-Amino-N-pyridin-3-ylbenzamide

HRID 1603767Notes

Reaction equation

HRID 1603767 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:16]=[CH:17][CH:18]=1)[C:7]([NH:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:8])([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:16]=[CH:17][CH:18]=1)[C:7]([NH:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:8]

Participants

4

Reactant 1

HCID 308753MLS000756500

Product 1

HCID 121094833-Amino-N-pyridin-3-ylbenzamideYield 86%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 3-(3-nitrobenzoylamino)-pyridine (2 g, 8.23 mmol) in ethanol (200 ml) was treated with 10% palladium on charcoal (0.5 g) and hydrogenated at atmospheric pressure for 4 h. Filtration and evaporation afforded the product as a white solid (1.51 g, 86%)

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-e7840f65ed22430b878c7d0c4872fc70
Source dataset
uspto-grants-1999_11
Patent number
US05990133

Reaction notes

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