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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1603776Generated: October 25, 2026

Urea → 5-Methylthio-6-trifluoromethyl-1-(3-ethoxycarbonylphenyl carbamoyl)-indoline

https://huagongshe.com/reaction/1603776

Reaction equation

Participants

RoleNameHCIDCharge
ReactantUreaHCID 1176—
ReactantEthyl 3-aminobenzoateHCID 11400—
ReactantBis-(1H-imidazol-2-YL)-methanoneHCID 5250894—
Reactant1H-Indole, 2,3-dihydro-5-(methylthio)-6-(trifluoromethyl)-HCID 10657270—
Product5-Methylthio-6-trifluoromethyl-1-(3-ethoxycarbonylphenyl carbamoyl)-indolineHCID 1800516074%

Reaction Steps

This was prepared in 74% yield by urea formation between ethyl 3-aminobenzoate and 5-methylthio-6-trifluoromethyl indoline, (D7) using carbonyl diimidazole as the coupling agent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05990133
Source datasetuspto-grants-1999_11
ORD IDord-130e2ce556eb4dae9065f57fbe12611a
Source noteuspto-grants-1999_11