2-Bromo-1-(3-nitrophenyl)ethan-1-one → 4-(3-Nitrophenyl)-2-(3-pyridyl)-thiazole hydrobromide

Participants

Reaction Steps

A mixture of 2-bromo-3'-nitroacetophenone (5 g, 20 mmol) and thionicotinamide (2.76 g, 20 mmol) in ethanol (25 ml) was heated to reflux for 1 h, during which time extensive precipitation occurred. Filtration and drying afforded the product as a yellow solid (6.7 g, 92%).

Provenance & Evidence