5-Methoxy-6-(trifluoromethyl)indoline → HCID 10528314, compound

HRID 1603792Notes

Reaction equation

HRID 1603792 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:20])OC2C=CC=CC=2)=[CH:7][C:6]=1[C:21]1[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:27][O:28][C:29]1[CH:30]=[C:31]2[C:35](=[CH:36][C:37]=1[C:38]([F:41])([F:40])[F:39])[NH:34][CH2:33][CH2:32]2>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([N:34]2[C:35]3[C:31](=[CH:30][C:29]([O:28][CH3:27])=[C:37]([C:38]([F:40])([F:41])[F:39])[CH:36]=3)[CH2:32][CH2:33]2)=[O:20])=[CH:7][C:6]=1[C:21]1[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=1)([CH3:2])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 112067135-Methoxy-6-(trifluoromethyl)indolineHCID 18005076HCID 18005076, compound

Product 1

HCID 10528314HCID 10528314, compoundYield 23%

Procedure

The title compound (0.055 g, 23%) was prepared from phenyl N-[4-t-butyl-3-(pyrid-3-yl)phenyl]carbamate (D22) (0.18 g, 0.00052 mole) and 5-methoxy-6-trifluoromethylindoline (D11) using the method of Example 28.

Sources & evidence

ORD record
ord-2113b4bbf6f3422da78b26af85f3fc2c
Source dataset
uspto-grants-1999_11
Patent number
US05990133

Reaction notes

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