5-Methoxy-6-(trifluoromethyl)indoline → HCID 10718089, compound

HRID 1603793Notes

Reaction equation

HRID 1603793 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:18])OC2C=CC=CC=2)=[CH:5][C:4]=1[C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1.[CH3:25][O:26][C:27]1[CH:28]=[C:29]2[C:33](=[CH:34][C:35]=1[C:36]([F:39])([F:38])[F:37])[NH:32][CH2:31][CH2:30]2>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([N:32]2[C:33]3[C:29](=[CH:28][C:27]([O:26][CH3:25])=[C:35]([C:36]([F:38])([F:39])[F:37])[CH:34]=3)[CH2:30][CH2:31]2)=[O:18])=[CH:5][C:4]=1[C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 112067135-Methoxy-6-(trifluoromethyl)indolineHCID 18005176HCID 18005176, compound

Product 1

HCID 10718089HCID 10718089, compoundYield 32%

Procedure

The title compound (0.21 g, 32%) was prepared from phenyl N-[4-methoxy-3-(pyrid-3-yl)phenyl]carbamate (D23) (0.48 g, 0.0015 mole) and 5-methoxy-6-trifluoromethylindoline (D11) using the method of Example 28.

Sources & evidence

ORD record
ord-cea4f77400e040cb8e5d0c3655ef6d74
Source dataset
uspto-grants-1999_11
Patent number
US05990133

Reaction notes

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