5-Methoxy-6-(trifluoromethyl)indoline → HCID 18005147, compound

HRID 1603794Notes

Reaction equation

HRID 1603794 reaction equation
[F:1][C:2]1[C:3]([O:24][CH3:25])=[C:4]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[CH:5]=[C:6]([NH:8][C:9](=[O:17])OC2C=CC=CC=2)[CH:7]=1.[CH3:26][O:27][C:28]1[CH:29]=[C:30]2[C:34](=[CH:35][C:36]=1[C:37]([F:40])([F:39])[F:38])[NH:33][CH2:32][CH2:31]2>>[F:1][C:2]1[C:3]([O:24][CH3:25])=[C:4]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[CH:5]=[C:6]([NH:8][C:9]([N:33]2[C:34]3[C:30](=[CH:29][C:28]([O:27][CH3:26])=[C:36]([C:37]([F:39])([F:40])[F:38])[CH:35]=3)[CH2:31][CH2:32]2)=[O:17])[CH:7]=1

Participants

3

Reactant 2

HCID 112067135-Methoxy-6-(trifluoromethyl)indolineHCID 18005132HCID 18005132, compound

Product 1

HCID 18005147HCID 18005147, compoundYield 53%

Procedure

The title compound (0.34 g, 53%) was prepared from phenyl N-[5-fluoro-4-methoxy-3-(pyrid-3-yl)phenyl)carbamate (D24) (0.48 g, 0.0014 mole) and 5-methoxy-6-trifluoromethylindoline (D11) using the method of Example 28.

Sources & evidence

ORD record
ord-2b95f9a0def04e6aa389086a8d6cfa6d
Source dataset
uspto-grants-1999_11
Patent number
US05990133

Reaction notes

Loading…