反应详情

To a solution of N-BOC-1,4-diaminobutane (8.324 g, 0.044 mol) in dry toluene (50 ml) was added maleic anhydride (4.336 g, 0.044 mol) and the solution heated at reflux under Dean-Stark conditions for two days. The solvent was removed and the residue purified by silica column chromatography eluting with 25-40% ethyl acetate in hexane to give the title compound, 1.461 g, 12%, as a white solid.

1. temperaturethe solution heated
2. temperatureat reflux under Dean-Stark conditions for two days
3. customThe solvent was removed
4. customthe residue purified by silica column chromatography
5. washeluting with 25-40% ethyl acetate in hexane