Dichloromethane → HCID 11110612, compound

Participants

Reaction Steps

To a flask containing N-[[4,5-dihydro-3-[4-[1,2,3,6-tetrahydropyridinyl]-phenyl]-5-isoxazolyl]methyl]acetamide (300 mg, 1.00 mmol) in methylene chloride (15 mL) and triethylamine (0.28 mL, 2.00 mmol) is added acetyl chloride (0.08 mL, 1.10 mmol) at 0° C. under an inert atmosphere. The reaction is warmed to ambient temperature stirred fifteen hours, concentrated in vacuo, and chromatographed on silica gel (230-400 mesh, 100 mL), eluting with chloroform/methanol (98/2). The appropriate fractions are combined (Rf =0.18, TLC, chloroform/methanol, 95/5) and concentrated in vacuo to give the title compound, HRMS calcd for C19H23N3O3 : 341.1739. Found: 341.7125.

Provenance & Evidence