Hydrochloric Acid → HCID 88232456, compound

Participants

Reaction Steps

A solution of benzimidazole (VIII: R=H) (1.00 g, 8.47 mmol) and 3-fluorobenzaldehyde (IX: R1' =3-CHO; halogen=F) (1.08 mL, 10.2 mmol) in DMSO (30 mL) was heated with anhydrous K2CO3 (2.34 g, 16.9 mmol) for 24 hours at 100° C. to give, after column chromatography on silica gel eluting with EtOAc/hexane (1:1) to EtOAc/hexane (3:1), Example 4 as the HCl salt, mp (EtOAc/MeOH) 196-201° C.

Provenance & Evidence