Water → 4-Nitrophenylglyoxal

HRID 1603856Notes

Reaction equation

HRID 1603856 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][CH:5]=1)=[O:3].[Se].[OH2:14]>>[N+:10]([C:7]1[CH:6]=[CH:5][C:4]([C:2]([CH:1]=[O:14])=[O:3])=[CH:9][CH:8]=1)([O-:12])=[O:11]

Participants

4

Reactant 3

HCID 962WaterHCID 7487p-NitroacetophenoneHCID 6326970Selenium

Product 1

HCID 1512424-Nitrophenylglyoxal

Procedure

6.60 (40 mmol) 4-nitroacetophenone was dissolved in 30 ml of diozane and 5 g, (45 mmol) selenium dioxyde was dissolved in 2.2 ml water and mixed. The mixture was refluxed for 16 hours with continuous stirring. The reaction mixture was passed through an alumina column to remove selenium. The solvent was evaporated in vacuum. The crude product was used in the next step without further purification.

Workup

  1. additionmixed
  2. temperatureThe mixture was refluxed for 16 hours with continuous stirring
  3. customto remove selenium
  4. customThe solvent was evaporated in vacuum
  5. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-ccfc521cb63f4e2589f2443f95c59f0d
Source dataset
uspto-grants-1999_11
Patent number
US05990141

Reaction notes

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