反应详情

温度

75 °C

A solution of 5-bromo-2-hydroxyacetophenone (23.7 g, 0.110 mol) in carbon tetrachloride (90 ml) was added with concentrated nitric acid (17.2 ml). The mixture was left under stirring at 75° C. for 50 minutes, then left to cool at room temperature. The precipitated solid was recovered by filtration washing with cold carbon tetrachloride. After drying under vacuum, 20.9 g of the title product were obtained as a light yellow solid (73% yield).

1. waitThe mixture was left
2. waitleft
3. temperatureto cool at room temperature
4. filtrationThe precipitated solid was recovered by filtration
5. washwashing with cold carbon tetrachloride
6. customAfter drying under vacuum