HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → 8-[2-(Benzyloxymethyl)benzofuran-5-carboxamido]-4-oxo-4H-1-benzopyran-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | N-(3-acetyl-2-hydroxyphenyl)-2-(benzyloxymethyl)benzofuran-5-carboxamide | HCID 19606326 | — |
| Reactant | ethyl 8-[2-(benzyloxymethyl)benzofuran-5-carboxamido]-4-oxo-4H-1-benzopyran-2-carboxylate | HCID 19606364 | — |
| Product | 8-[2-(Benzyloxymethyl)benzofuran-5-carboxamido]-4-oxo-4H-1-benzopyran-2-carboxylic acid | HCID 19606333 | — |
Reaction Steps
Following the process described in example 1 (point A), starting from N-(3-acetyl-2-hydroxyphenyl)-2-(benzyloxymethyl)benzofuran-5-carboxamide and diethyl oxalate, ethyl 8-[2-(benzyloxymethyl)benzofuran-5-carboxamido]-4-oxo-4H-1-benzopyran-2-carboxylate was prepared which was subsequently hydrolysed according to the process described in example 1 (point M) to yield the title compound as a white solid with melting point 215-218° C. (65% global yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05990142 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-c80e4b8ab5f840fe8016c9da09487413 |
| Source note | uspto-grants-1999_11 |