Hydrochloric Acid → HCID 19606346, compound

Participants

Reaction Steps

A solution of ethyl 2-benzyloxymethyl-2,3-dihydrobenzofuran-2-carboxylate (1.62 g, 5.47 mmol) in methanol (70 ml) was added with a solution of 1M lithium hydroxide (54.7 ml). The mixture was refluxed under stirring for 3 h, after that was neutralized with 1M HCl and methanol was evaporated off under reduced pressure. The resulting crude was suspended in water (20 ml) and extracted with ethyl acetate (4×25 ml). The organic phase was dried and the solvent was evaporated off under reduced pressure, to obtain 1.436 g of the title compound, which was purified by crystallization in methanol (97% yield).

Provenance & Evidence