Hydrochloric Acid → HCID 178521895, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-[4-oxo-2-cyano-4H-1-benzopyran-8-yl]-2-benzyloxymethyl-2,3-dihydrobenzofuran-5-carboxamide (300 mg, 0.66 mmol), sodium azide (129 mg, 1.99 mmol), ammonium chloride (107 mg, 1.99 mmol) and dry N,N-dimethylformamide (10 ml) was left under stirring at 100° C. for 1.25 h. After that the mixture, cooled at room temperature, was poured onto a 1M hydrochloric acid solution (10 ml), recovering by filtration the formed precipitate, thereby obtaining 111 mg of the title compound as a white solid with melting point 200-202° C., which was purified by crystallization in methanol:dichloromethane mixtures (68% yield).

Provenance & Evidence