Phenethyl bromide → HCID 19606272, compound

HRID 1603902Notes

Reaction equation

HRID 1603902 reaction equation
FC(F)(F)S(O[CH2:7][CH:8]1[CH2:12][C:11]2[CH:13]=[C:14]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:15]=[CH:16][C:10]=2[O:9]1)(=O)=O.Br[CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[C:27]1([CH2:26][CH2:25][CH2:7][CH:8]2[CH2:12][C:11]3[CH:13]=[C:14]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:15]=[CH:16][C:10]=3[O:9]2)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 7666Phenethyl bromideHCID 19606276HCID 19606276, compound

Product 1

HCID 19606272HCID 19606272, compoundYield 75%

Procedure

Following the process described in example 3 (point B), starting from ethyl 2-trifluoromethanesulfonyloxymethyl-2,3-dihydrobenzofuran-5-carboxylate and 2-bromoethylbenzene, the title compound was prepared, which was purified by chromatography through a silica gel column, eluting with n-hexane:ethyl acetate, 95:5 (75% yield).

Workup

  1. customwhich was purified by chromatography through a silica gel column
  2. washeluting with n-hexane

Sources & evidence

ORD record
ord-8da86d811e2345428e2a1ce10f236617
Source dataset
uspto-grants-1999_11
Patent number
US05990142

Reaction notes

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