3-Amino-2-hydroxyacetophenone → HCID 19606330, compound

HRID 1603903Notes

Reaction equation

HRID 1603903 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH:10]2[CH2:14][C:13]3[CH:15]=[C:16]([C:19]([OH:21])=O)[CH:17]=[CH:18][C:12]=3[O:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:22][C:23]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([NH2:31])[C:26]=1[OH:32])=[O:24]>>[C:23]([C:25]1[C:26]([OH:32])=[C:27]([NH:31][C:19]([C:16]2[CH:17]=[CH:18][C:12]3[O:11][CH:10]([CH2:9][CH2:8][CH2:7][C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[CH2:14][C:13]=3[CH:15]=2)=[O:21])[CH:28]=[CH:29][CH:30]=1)(=[O:24])[CH3:22]

Participants

3

Reactant 2

HCID 4592943-Amino-2-hydroxyacetophenoneHCID 19606257HCID 19606257, compound

Product 1

HCID 19606330HCID 19606330, compoundYield 60%

Procedure

Following the process described in example 1 (point K), starting from 2-(3-phenylpropyl)-2,3-dihydrobenzofuran-5-carboxylic acid and 3-amino-2-hydroxyacetophenone, the title compound was prepared (60% yield).

Sources & evidence

ORD record
ord-0c9dde743f984eb1a67e6d6728e1523a
Source dataset
uspto-grants-1999_11
Patent number
US05990142

Reaction notes

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