Hydrochloric Acid → HCID 19606349, compound

Participants

Reaction Steps

A solution of ethyl 2-benzylthiomethyl-2,3-dihydrobenzofuran-2-carboxylate (2.70 g, 8.53 mmol) in ethanol (100 ml) was added with a solution of 1M potassium hydroxide. (42.6 ml). The mixture was refluxed under stirring for 3 h, after that was neutralized with 1M HCl and ethanol was evaporated off under reduced pressure. The resulting crude was suspended in water (30 ml) and extracted with ethyl acetate (4×30 ml). The organic phase was dried and the solvent was evaporated off under reduced pressure, to obtain 2.172 g of the title compound as a brown solid with melting point 125-127° C. (85% yield).

Provenance & Evidence