HCID 19606262, compound → HCID 19606353, compound

Participants

Reaction Steps

Following the process described in example 6 (point B), starting from 4-allyloxy-2-chlorobenzonitrile, a mixture of 5-allyl-2-chloro-4-hydroxybenzonitrile and 3-allyl-2-chloro-4-hydroxybenzonitrile was obtained. The two isomers were separated by chromatography through a silica gel column. Eluting with petroleum ether:ethyl ether, 8:2, the isomer 5-allyl-2-chloro-4-hydroxybenzonitrile (39% yield) was recovered and eluting with petroleum ether:ethyl ether, 6:4, the isomer 3-allyl-2-chloro-4-hydroxybenzonitrile was recovered (51% yield).

Provenance & Evidence